Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).
Prof. Dr. Iris Augustin,
Dyah L. Dewi,
Jennifer Hundshammer,
Eugen Rempel,
Fabian Brunk,
Michael Boutros
Berechtigungen: Open Access
Berechtigungen: Peer Reviewed
Immune cell recruitment in teratoma is impaired by increased Wnt secretion (2016) Stem Cell Research 17 (3), S. 607-615.
DOI: 10.1016/j.scr.2016.10.010
Wnt signaling plays a central role in tumor initiation and tumor progression. Mutations in Wnt pathway components, such as the tumor suppressor APC, lead to malignant transformation. While previous studies focused on Wnt-related changes in cancer cells, the impact of aberrant Wnt signaling on the tumor microenvironment is only beginning to emerge. In order to investigate the role of increased Wnt secretion on tumor growth and the microenvironment, we generated a novel germ cell tumor model by overexpressing the Wnt secretion factor Evi/Wls in mouse embryonic stem cells. Evi-overexpressing teratoma were characterized by enhanced tumor growth in supporting a tumor-promoting role of Wnt secretion. Interestingly, enhanced Evi expression correlated with impaired immune cell recruitment. Specifically, T- and B-cell infiltration was reduced in Evi-overexpressing teratomas, which was independent of teratoma size and differentiation. Our study suggests that Wnt secretion impairs immunosurveillance. Since immune cell infiltration has been shown to have prognostic value, the levels of secreted Wnt activity might impact the efficiency of cancer immunotherapy.
F. Schwertner,
Prof. Dr. Sabine Grüner-Lempart,
J. Schulmeyr,
M. Klasik,
N. Igl
Berechtigungen: Peer Reviewed
Fractionation of phytoextracts by a counter-current column using CO2; 15th European Meeting on Supercritical Fluids (2016) 15th European Meeting on Supercritical Fluids, Essen; 8. – 11. Mai 2016 .
Beate Scholz,
Claudia Korn,
Jessica Wojtarowicz,
Carolin Mogler,
Prof. Dr. Iris Augustin,
Michael Boutros,
Christof Niehrs,
Hellmut G. Augustin
Berechtigungen: Open Access
Berechtigungen: Peer Reviewed
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca2+/NFAT Signaling (2016) Developmental Cell 36 (1), S. 79-93.
DOI: 10.1016/j.devcel.2015.12.015
Prof. Dr. Martin Krottenthaler
Gezielte Beeinflussung. Auswirkungen des Brauwassers auf die Bierqualität (2015) Brauindustrie 100 , S. 58-60.
Fabian Brunk,
Prof. Dr. Iris Augustin,
Michael Meister,
Michael Boutros,
Bruno Kyewski
Berechtigungen: Peer Reviewed
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development (2015) The Journal of Immunology 195 (11), S. 5261-5271.
DOI: 10.4049/jimmunol.1501265
Cornelia Welzmiller,
Stefan Kilian,
Prof. Dr. Matthias Kunert
Faktoren des Erfolgs – Eine Analyse des brauwirtschaftlichen Mittelstands (2015) Brauindustrie 100 (10), S. 24-27.
F. Schwertner,
Prof. Dr. Sabine Grüner-Lempart,
J. Schulmeyr,
M. Klasik,
N. Igl
Berechtigungen: Peer Reviewed
Fractionation of extracts by counter-current columns (2015) 54th Tutzing Symposion 2015: Sustainable Phyto Extracts – Trends, Perspectives and Visions; Tutzing; 27. – 30. September 2015 .
Dr. Michael Krappmann,
Prof. Dr. Frank Leßke,
Dipl. Ing. (FH) Marco Luthardt,
PD Dr. Thomas Letzel
Berechtigungen: Open Access
Berechtigungen: Peer Reviewed
The Software-Landscape in (Prote)Omic Research (2015) Journal of Proteomics & Bioinformatics 8 (7), S. 164-175.
DOI: 10.4172/jpb.1000365
(Bio)Informatics plays a major role in (prote)omic research experiments and applications. Analysis of an entire proteome including protein identification, protein quantification, detecting biological pathways, metabolite identification and others is not possible without software solutions for analyzing the resulting huge data sets. In the last decade plenty of software-tools, -platforms and databases have been developed by vendors of analytical hardware, as well as by freeware developers and the open source software community. Some of these software packages are very much specialized for one (omic) topic, as for example genomics, proteomics, interactomics or metabolomics. Other software tools and platforms can be applied in a more general manner, e.g. for generating workflows, or performing data conversion and data management, or statistics. Nowadays the main problem is not to find out a way, how to analyze the experimental data, but to identify the most suitable software for this purpose in the vast software-landscape. This review focuses on the following issue: How complex is the link between biology, analysis and (bio) informatics, and how complex is the variety of software tools to be used for scientific investigations, starting from microorganisms up to the detection of a proteome. Thereby the main emphasis is on the variety in software for (LC) MS(/MS) proteomics. In the World Wide Web sites like ExPASy show extensive lists of proteomics software, leaving it to the user to identify which software actually serves their purposes. First we consider the huge variability of software in the field of proteomics research. Then we take a closer look on the variability of MS data and the incompatibilities of software tools with respect to that. We give an overview over commonly used software technologies and finally end up with the question, whether open source software would not add more value to this field.
Betreuung der Publikationsseiten
Gerhard Radlmayr
Referent für Wissenstransfer und Forschungskommunikation
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