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Veröffentlichungen der HSWT

Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).

8 Ergebnisse

  • Nils Brose, Prof. Dr. Iris Augustin, Christian Rosenmund, Thomas C. Südhof

    • Berechtigungen:  Peer Reviewed

    Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles (1999) Nature 400 , S. 457-461. DOI: 10.1038/22768

    Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered exocytotic fusion of synaptic vesicles1. Before fusion, vesicles dock at the presynaptic release site where they mature to a fusion-competent state1,2. Here we identify Munc13-1, a brain-specific presynaptic phorbol ester receptor3,4, as an essential protein for synaptic vesicle maturation. We show that glutamatergic hippocampal neurons from mice lacking Munc13-1 form ultrastructurally normal synapses whose synaptic-vesicle cycle is arrested at the maturation step. Transmitter release from mutant synapses cannot be triggered by action potentials, calcium-ionophores or hypertonic sucrose solution. In contrast, release evoked by α-latrotoxin is indistinguishable from wild-type controls, indicating that the toxin can bypass Munc13-1-mediated vesicle maturation. A small subpopulation of synapses of any given glutamatergic neuron as well as all synapses of GABA (γ-aminobutyric acid)-containing neurons are unaffected by Munc13-1 loss, demonstrating the existence of multiple and transmitter-specific synaptic vesicle maturation processes in synapses.

  • Prof. Dr. Oliver Christ, Prof. Dr.-Ing. Martin Faulstich, P. A. Wilderer

    Mathematical Modelling of the hydrolysis of anaerobic processes (1999) 2nd International Symposium on Anaerobic Digestion of Solid Waste, Barcelona, 15-18 June 1999 , S. 5-8.

  • Prof. Dr. Monika Gerschau

    Erfolgsfaktoren für regionale Vermarktungsprojekte (1999) Beraterfortbildung an der Landesanstalt für Entwicklung der Landwirtschaft und der ländlichen Räume in Schwäbisch Gmünd, 15.06.1999 .

  • Prof. Dr. Martin Krottenthaler, Joachim Zürcher, Werner Back, Jan Schneider, Horst Weisser

    Grist Fractionating and Adjusted Mashing to Improve the Reduction of b-Glucan (1999) Proceedings of the 27th Congress - European Brewery Convention. Cannes, France, 1999 , S. 603-610.

  • Martin Pusch, C. Feld, Prof. Dr. Andreas Hoffmann

    • Berechtigungen:  Peer Reviewed

    Schwemmgut - kostenträchtiger Müll oder wertvolles Element von Flußökosystemen? (1999) Wasserwirtschaft 89 (6), S. 280-284.

  • Prof. Dr. Marion Stoffels-Schmid, Wolfgang Ludwig, Karl-Heinz Schleifer

    • Berechtigungen:  Peer Reviewed

    rRNA Probe Based Cell Fishing of Bacteria (1999) Environmental Microbiology 1 (3), S. 259-271. DOI: 10.1046/j.1462-2920.1999.00032.x

  • Nicola Fohrer, Prof. Dr. Klaus Eckhardt, S. Haverkamp, Hans-Georg Frede

    Applying the SWAT Model as a Decision Support Tool for Land Use Concepts in Peripheral Regions in Germany (1999) Sustaining the global farm - Selected papers from the 10th International Soil Conservation Organization Meeting, May 24-29, 1999, West Lafayette (Indiana, USA) , S. 994-999.

Betreuung der Publikationsseiten

Zentrum für Forschung und Wissenstransfer - Lageplan in Weihenstephan an der HSWT

Kontakt

Hochschule Weihenstephan-Triesdorf
Zentrum für Forschung und Wissenstransfer
Gebäude H21
Am Staudengarten 9
85354 Freising

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