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Veröffentlichungen der HSWT

Die chronologische Liste zeigt aktuelle Veröffentlichungen aus dem Forschungsbetrieb der Hochschule Weihenstephan-Triesdorf. Zuständig ist das Zentrum für Forschung und Wissenstransfer (ZFW).

8 Ergebnisse

  • Michael Anees, M.Sc. Maresa Bussa, Cristina Dominguez, Marco Duran, Mandar Kadam, Luis Rojas-Solórzano

    Solar Water Heating for Aquaculture Applications in Cold Climates: A Case Study of Finland (2018) The Role of Exergy in Energy and the Environment. Green Energy and Technology. Springer, Cham , S. 573-587. DOI: 10.1007/978-3-319-89845-2_40

  • Georg Kaufmann, Douchko Romanov, Thomas Tippelt, Prof. Dr. Thomas Vienken, Ulrike Werban, Prof. Dr. Peter Dietrich, Franziska Mai, Frank Börner

    • Berechtigungen:  Peer Reviewed

    Mapping and modelling of collapse sinkholes in soluble rock: The Münsterdorf site, northern Germany (2018) Journal of Applied Geophysics 154 , S. 64-80. DOI: 10.1016/j.jappgeo.2018.04.021

    Münsterdorf is a small village in the north of Hamburg, located along the northern rim of a salt diapir. The Permian rocks are uplifted and overlying rocks such as the Cretaceous limestone, normally at several kilometers depth, have been pushed close to the surface. In Münsterdorf, the Cretaceous limestone can be found at around 20 m depth, and about 2 km further south, Cretaceous limestones are quarried in a large open-pit mine.Since 2004, collapse sinkholes have formed on a sports field in Münsterdorf, with a frequency of about 1 every two years, about 3–5 m in diameter and 3–5 m deep. The collapse sinkholes do not reach the underlying limestone, but seem to be related to accelerated dissolution in that formation. Above the Cretaceous limestone, Quaternary gravels and glacial tills provide a non-soluble, but permeable and heterogeneous cover of about 20 m thickness.We have mapped the sports field and its vicinity with gravity (GRAV), electrical resistivity imaging (ERI), and ground-penetrating radar (GPR). The ERI profiles indicate a significant change in the surface layer, from thin and irregular in the northern part to thicker and more homogeneous in the southern part of the sports field. GPR profiles confirm this result.We numerically model the evolution of flow and porosity in the Cretaceous limestone to estimate the evolution time of subsurface voids in the limestone, and we discuss the potential cause of the sinkhole formation and its sudden onset in light of the hydraulic boundary conditions.
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  • Elena Castellanos-Rizaldos, Prof. Dr. Dominik Grimm, Vasisht R. Tadigotla, James Hurley, John Healy, Patricia L. Neal, Mia Sher, Raajdeep Venkatesan, Chris Karlovich, Mitch Raponi, Anne Krug, Mikkel Noerholm, Jihane Tannous, Bakhos A. Tannous, Luis E. Raez, Johan K. Skog

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Exosome-Based Detection of EGFR T790M in Plasma from Non–Small Cell Lung Cancer Patients (2018) Clinical Cancer Research 24 (12), S. 2944-2950. DOI: 10.1158/1078-0432.CCR-17-3369

    Purpose: About 60% of non–small cell lung cancer (NSCLC) patients develop resistance to targeted epidermal growth factor receptor (EGFR) inhibitor therapy through the EGFR T790M mutation. Patients with this mutation respond well to third-generation tyrosine kinase inhibitors, but obtaining a tissue biopsy to confirm the mutation poses risks and is often not feasible. Liquid biopsies using circulating free tumor DNA (cfDNA) have emerged as a noninvasive option to detect the mutation; however, sensitivity is low as many patients have too few detectable copies in circulation. Here, we have developed and validated a novel test that overcomes the limited abundance of the mutation by simultaneously capturing and interrogating exosomal RNA/DNA and cfDNA (exoNA) in a single step followed by a sensitive allele-specific qPCR.Experimental Design: ExoNA was extracted from the plasma of NSCLC patients with biopsy-confirmed T790M-positive (N = 102) and T790M-negative (N = 108) samples. The T790M mutation status was determined using an analytically validated allele-specific qPCR assay in a Clinical Laboratory Improvement Amendment laboratory.Results: Detection of the T790M mutation on exoNA achieved 92% sensitivity and 89% specificity using tumor biopsy results as gold standard. We also obtained high sensitivity (88%) in patients with intrathoracic disease (M0/M1a), for whom detection by liquid biopsy has been particularly challenging.Conclusions: The combination of exoRNA/DNA and cfDNA for T790M detection has higher sensitivity and specificity compared with historical cohorts using cfDNA alone. This could further help avoid unnecessary tumor biopsies for T790M mutation testing.

  • Prof. Dr. habil. Carsten Lorz, M. Heckner

    • Berechtigungen:  Peer Reviewed

    The Training Forest Trail of the Department of Forestry, Hochschule Weihenstephan-Triesdorf, University of Applied Sciences, Germany (2018) SILVA 2018 Technische Universität Dresden, Tharandt, Sächsische Landesbibliothek − Staats- und Universitätsbibliothek, Dresden 2018 .

  • Katrin Reincke, Elisa Vilvert, Prof. Dr. Anja Faße, Frieder Graef, Stefan Sieber, Marcos Alberto Lana

    • Berechtigungen:  Open Access
    • Berechtigungen:  Peer Reviewed

    Key factors influencing food security of smallholder farmers in Tanzania and the role of cassava as a strategic crop (2018) Food Security 10 , S. 911-924. DOI: 10.1007/s12571-018-0814-3

  • Florian D. Schwahn, Prof. Dr. Clemens Thielen

    • Berechtigungen:  Peer Reviewed

    The Complexity of Escaping Labyrinths and Enchanted Forests (2018) Konferenzbeitrag zu Proceedings of the 9th International Conference on Fun with Algorithms (FUN) 2018 (100), S. 1-13. DOI: 10.4230/LIPIcs.FUN.2018.30

  • Götz Uckert, Frieder Graef, Prof. Dr. Anja Faße, Ludger Herrmann, Harry Hoffmann, Frederick C. Kahimba, Dr. Luitfred Kissoly, Hannes König, Christine Lambert, Henry Mahoo, Bashir Makoko, Leon Mrosso, Khamaldin Daud Mutabazi, Lutengano Mwinuka, Meike Schaefer, Jana Schindler, Stefan Sieber, Elirehema Swai, Yusto Mugisha Yustas

    • Berechtigungen:  Peer Reviewed

    ScalA-FS: expert-based ex-ante assessments of local requirements and success potential of upgrading strategies for improving food security in rural Tanzania (2018) Food Security 10 , S. 841-858. DOI: 10.1007/s12571-018-0789-0

  • Arne Herzel, Michael Hopf, Prof. Dr. Clemens Thielen

    • Berechtigungen:  Peer Reviewed

    Multistage interval scheduling games (2018) Journal of Scheduling 2018 (22), S. 359-377. DOI: 10.1007/s10951-018-0568-y

Betreuung der Publikationsseiten

Zentrum für Forschung und Wissenstransfer - Lageplan in Weihenstephan an der HSWT

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Hochschule Weihenstephan-Triesdorf
Zentrum für Forschung und Wissenstransfer
Gebäude H21
Am Staudengarten 9
85354 Freising

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